$B!!%S!<%P%s%8%g%QIJ(B ">

$B<+A3?)IJ@lLgE9$/$k$_$d!V3ZE7E9!W%*!<%W%s(B$B$4MxMQ$/$@$5$$(B


$B!!!!!!(B
$B!!!!!!!!!!!!!!!!!!(B$B"#(B$B!X%S!<%P%s%8%g%"!Y$O%U%i%s%98l$G!X@8$-$k4n$S!Y$N0UL#$G$9!#(B
$B!!!!!!!!!!!!!!!!!!(B$B"#(B$B!X%S!<%P%s%8%g%"!Y$O!X7r9/H)2=>QIJ!Y$N%V%i%s%I$G$9!#(B
$B!!!!!!!!!!!!!!!!(B$B!!(B$B"#(B$B!X%S!<%P%s%8%g%"!Y$OBgG>$G$O$J$/HiIf:YK&$N%9%?%s%9$G9M$($^$9!#(B
$B!!!!!!!!!!!!!!!!!!!!!!(B$B$@$+$i!"3&LL3h@-:^$dCO5e4D6-$K$3$@$o$k$N$G$9!#(B
$B!!!!!!!!!!!!!!!!!!(B$B"#(B$B!X7r9/H)2=>QIJ!Y$OHiIf$,K\Mh;}$C$F$$$k%[%a%*%9%?%7%9$r%5%]!<%H$7!"(B
$B!!!!!!!!!!!!!!!!!!!!(B$B!!(B$BHiIf5!G=$r7rA4$KJ]$A!"QIJ$G$9!#(B
$B!!!!!!!!!!!!!!!!!!(B$B"#(B$B!X%S!<%P%s%8%g%"7r9/H)2=>QIJ!Y$O$=$l$>$l$NH)
$B!!!!!!!!!!!!!!!!!!!!!!(B$B8z$-L\$N3N$+$5$G$4K~B-$$$?$@$1$^$9!#(B
$B!!!!(B

$B%[%a%*%9%?%7%9!'(Bhomeostasis

$B!V91>o@-0];}5!G=!W$N0UL#(B

$B@8L?BN$O@8BN$N91>o@-$rJ]$D$?$a$K<+$i$NNO$GFbIt4D6-$r@0$(0];}$7$h$&$H$9$kNO$,F/$-$^$9!#(B
$B@8BN$K6/$$%@%a!<%8$,@8$8$?$H$-!"<+N'?@7P7O!"%[%k%b%s7O!"LH1V7O$H$$$C$?$"$i$f$kLL$+$i%P%i%s%9$r(B
$B2sI|$5$;$k$?$a$NF/$-$,@8$8$^$9!#(B

$B$3$N$h$&$J@8BN$,<+$iM-$7$F$$$k%U%#!<%I%P%C%/:nMQ$r91>o@-5!G=!J%[%a%*%9%?%7%9!K$H$$$$$^$9!#(B
$BFC$KHiIf$O>o$K303&$H$N6-3&$K0LCV$7$F$*$j!"30It4D6-$NJQ2=$K:G$b$5$i$5$l$d$9$$$?$a!"(B
$B6/$$%[%a%*%9%?%7%95!G=$rM-$7$F$$$^$9!#(B

$B%[%a%*%9%?%7%9:nMQ$,?j$($k$HHiIf$,O72=$7$^$9!#(B
$B7r9/H)2=>QIJ$O$3$N%[%a%*%9%?%7%9:nMQ$r%5%]!<%H$7!"HiIf$N7r9/$H


$B-!2=>Q$9$k$N$O!"<+$i$NH~$7$5$N$?$a$G$9!#(B$B-"H~$7$5$O!"5f6KH)G/Np$No$K!"@67i(B
$B$G7r9/$KJ]$D$3$H$G$9!#-$HiIf$N7r9/$O!"%[%a%*%9%?%7%9!J91>o@-0];}5!G=!K$K$h$j!"HiIf5!G=$,7rA4$K0];}$5$l$k$3$H$G$9!#(B

$B-%HiIf5!G=$O!'(B$B%P%j%"5!G=(B$B!'(B$B?7@8!&Be$B-&%P%j%"5!G=$H$O!'30$N2a9s$J4D6-$+$iL?$r $B5!G=$G$9!#-'HiIf%P%j%"5!G=$H$O!'(B$B"#(B$B4%Ag(B$B"#(B$B;g30@~(B$B"#(B$B3h@-;@AG(B$B"#(B$B%_%/%m$N@8L?BN(B[$B%&%$%k%9!"%P%$6]!"%"%l%k%2%s(B]
$B"#(B$BM-322=3XJ*$B"#(B$BEE<'GH(B$B-)%[%a%*%9%?%7%9!'2a9s$J304D6-$rKI8f$9$k$?$a$KBg$-$J%9%H%l%9$,$+$+$j!"HiIf5!G=$,?j$($^$9!#(B
$BHiIf$O<+$i$NNO!J%[%a%*%9%?%7%9%Q%o!
$B-*O72=$NH/@8!'%[%a%*%9%?%7%9$NNO$,?j$($k$HO72=$,;O$^$j$^$9!#(B
$B-+7r9/H)2=>QIJ!'%[%a%*%9%?%7%9$N%Q%o!<$r%5%]!<%H$7$F!"H)$r7r9/$KJ]$A!"H)G/Np$r $B$k$b$N$G$9!#(B


$B%/%l%s%8%s%0!&@v4i!&%Q%C%/(B
$B $BHy%"%k%+%j@-(B
$B!Z#1![%"%_%N;@%*%$%k%/%l%s%8%s%0(B
$B"#%S!<%P%s%8%g%"#2#1#2"#(B		 $B!Z(B2$B![9ZAG@v4i(BC$B%Q%&%@!<(B
$B"#(B$B%S!<%P%s%8%g%"#2#0#1(BC$B"#(B
$B!Z$B!ZL}@-![(B

$B!Z

$B#1#0#0#m#l!!!!#5!$#0#0#01_(B
$B!Z
$B!Z%Q%&%@!

$B!Z $B%"%_%N;@7O@v>t@.J,!&%Q%Q%$%s9ZAG(B$B!&(B$B1v2=%j%>%A!<%`9ZAG!&3$At%(%-%9(B
$B#1#0#0#g!!!!#3!$#8#0#01_(B

$B!Z(B$BJ,Jq%?%$%W![(B
$B1x$l$r%*%$%k$GIb$+$;!"?e$rFk@w$^$;$J$,$i@v$$Mn$H$7$^$9!#(B
$B%"%_%N;@7O%*%$%k$O?e$K$J$8$_$d$9$/!" $B@v$$>e$,$j$N$*H)$O$7$C$H$j=a$$$^$9!#(B
$BNI$/K"N)$F!"K"$GJq$_9~$`$h$&$K$7$F@v$$$^$9!#(B
$BHy%"%k%+%j@-$G$9$+$iLS7j$d3Q $BK"N)@lMQ$N%U%)!<%_%s%0%7%'!<%+!<$r$4;HMQ$K$J$k$H4JC1$K$-$l$$$JK"$,$D$/$l$^$9!#(B
$B%/%l%s%8%s%0!&@v4i!&%Q%C%/(B
$BHy%"%k%+%j@-(B $BH~!!Gr(B
$B!Z(B3$B![%T%e%"%=!<%W(B
$B"#%S!<%P%s%8%g%"#2#5#2(BM$B"#(B		 $B!Z#4![(BMK$B%*%&%4%s%Q%C%/(B
$B"#%S!<%P%s%8%g%"(B280$B"#(B
$B!Z$B!Z?e@-![(B

$B!Z $BE7A3L};i@P84!&%*%&%4%s(B

$B#1#0#0(Bg$B!!#1!$#2#0#01_(B
$B!Z

$B!Z MK$BN3;R!J%1%$;@%"%k%_%K%&%`%^%0%M%7%&%`!"%+%k%7%&%`!K(B
$B%*%&%4%s!&%R%"%k%m%s;@(B

$B#1#8#0#g!!#8!$#0#0#01_(B
$B%T%e%"$J@:@=L};i$+$iFCJL$N@=K!$G$D$/$kDc%"%l%k%.!<@-$NF)L@@P84$G$9!#%G%j%1!<%H$J$*H)$d@V$A$c$s$K$b0B?4$7$F;H$($^$9!#A4?H@v$$$K$b$*;H$$2<$5$$!#HiIf$NJ]<>@.J,$r
$BF~Ma;~$K#5J,$+$i#1#0J,%Q%C%/$7$F@v$$N.$7$^$9!#(B
MK$BN3;R$,I=Hi$N8E$$3Q $BKhF|$9$k$H$h$j8z2LE*$G$9!#(B
$B!ZH~Gr![%7%_!&$/$9$_$N$J$$F)L@AGH)(B$B!!!!(B$B!ZL5E:2C![I=<(;XDj@.J,L5E:2C(B$B!!!!(B$B!ZH~H)![$7$_!&$?$k$_$N$J$$CFNOAGH)(B
$B@0!!H)(B
$B(B $BH~!!Gr(B
$B!Z#5![
$B"#%S!<%P%s%8%g%"#3#1#4"#(B		 $B!Z#6![%7%_@lMQ(BMK$B%m!<%7%g%s(B
$B"#%S!<%P%s%8%g%"#3#0#1"#(B
$B!Z$B!Z?e@-![(B

$B!Z $B=c?h$X$A$^?e!&%7%3%s!&%*%&%4%s(B
$B%=%&%O%/%R(B

$B#1#2#0#m#l!!#4!$#5#0#01_(B
$B!Z$B!Z?e@-![(B

$B!Z MK$BN3;R!JFC

$B#3#0#m#l!!#1#2!$#0#0#01_(B
$B@v4i8e$N$*H)$ruBV$KJ]$A$^$9!#(B
$B$*H)$N%-%a$r@0$(!"H)9S$l$rKI$.$^$9!#=c?h$X%A%^?e$O%X%A%^$N7T$+$i:N
$B@v4i8eKt%Q%C%/8e5$$K$J$kIt0L$rCf?4$K$?$C$W$j$D$1$^$9!#(B
$B%7%_$N860x$K$J$C$F$$$kI=Hi$N8E$$3Q

$B@0!!H)(B
$BH~!!Gr(B $BH~!!H)(B
$B!Z#7![(BMK$B%[%o%$%H%(%C%;%s%9(B
$B"#%S!<%P%s%8%g%"#0#0#3"#(B		 $B!Z#8![%P%$%*%j%s%/%k%(%C%;%s%9(B
$B"#%S!<%P%s%8%g%"#3#6#0"#(B
$B!Z$B![(B$B!Z?e@-![(B
$B!J%^%$%/%m%+%W%;%kF~$j!K(B
$B!Z MK$BN3;R!J%1%$;@%"%k%_%K%&%`!K!&3$At%+%W%;%k!&%$%=%U%i%\%s!&G"AG(B

$B#3#0#m#l!!#1#0!$#0#0#01_(B
$B!Z$B!Z?e@-![(B
$B!Z M$B%h!<%0%k%H%(%-%9!&F};@!&%$%=%U%i%\%s!&%*%&%4%s!&?"J*@-%W%i%;%s%?MM%(%-%9(B

$B#4#0#m#l!!#1#8!$#0#0#01_(B
$B3$At%+%W%;%kCf$N(BMK$BN3;R$,%a%i%K%s$J$I$*H)$N1x$l$r%$%*%s$NNO$G0z$-=P$7!"BgF&M3Mh$N%$%=%U%i%\%s$,H)%[%k%b%s$NF/$-$r3hH/$K$7$F$*H)$r$7$C$H$j=a$o$;$J$,$i!"%O%j$N$"$kF)L@AGH)$K6a$E$1$F$$$-$^$9!#(B
$B$*H)$NI=Hi$O2CNp$d4%Ag!";g30@~Ey$K$h$j=y!9$K7A>u$,JQ2=$7$F$$$-$^$9!#D+!"LkKhF|$N$4;HMQ$G!"L\?,$dL\85!"8}2s$j$J$I5$$K$J$kIt0L$NHiIfAH?%$K%O%j$HCFNO$r;}$?$;!"H)G/Np$r
$B@0!!H)(B
$BH~!!H)(B $BDC!!@E(B
$B!Z#9![%U%k!<%D;@%P%$%*%(%C%;%s%9(B
$B"#%S!<%P%s%8%g%"#3#8#0"#(B		 $B!Z#1#0![LtMQ!&H~GrJ]<>%8%'%k(B
$B"#%S!<%P%s%8%g%"#3#0#8"#(B
$B!Z$B!Z?e@-![(B

$B!Z $B%U%k!<%D;@!J(BAHA)
$B?"J*%;%i%_%I(B
$B%*%&%4%s(B
40ml$B!!#8!$#8#0#01_(B
$B!Z$B!Z?e@-![(B

$B!Z $B%0%j%A%k$j%A%s;@%8%+%j%&%`!&%*%&%4%s!&%$%=%U%i%\%s!&%&%$%-%g%&!&%f%-%N%7%?(B

$B#5#0#g!!#1#2!$#0#0#01_(B
$B#A#H#A$,Hn8|$7$?8E$$3Q $B<~4|$N%?!<%s%*!<%P!<$,B%?J$5$l!"?7A/$JHiIf$,(B
$BAI$j$^$9!#(B
$B%H%i%V%kH)$N3Q $B6/$$7r9/H)$r0];}$7$^$9!#(B
$BF|>F$18e$N1j>I$d?'AGD@Ce$rKI;_$7!"H)9S$l$d(B
$B%K%-%S!"%H%i%V%kH)$N1j>I$rDC$a$^$9!#HiIfI=LL(B
$B$N4D6-$rNI9%$KJ]$AH) $BL}J,$r4^$^$J$$%&%*!]%?!<%Y!<%9$N$8$s$d$j5$;}$A(B
$B$$$$%8%'%k$G$9!#(B
$B@0!!H)(B
$B4%AgIR46H)J]<>(B $B4%Ag2CNpH)J]<>(B
$B!Z(B11$B![%"%/%"%U%#%k%`%m!<%7%g%s(B
$B"#%S!<%P%s%8%g%"#3#1#8"#(B		 $B!Z(B12$B![%(%b%j%(%s%H%/%j!<%`(B
$B"#%S!<%P%s%8%g%"(B311$B"#(B
$B!Z$B!Z?e@-![(B
$B!ZA4?HMQ%9%W%l!<%?%$%W![(B

$B!Z $B&B!]%T%e%"%-%H%5%s!&?"J*@-%;%i%_%I!&F};@!&#P#C#A!]#N(Ba

$B#1#5#0#m#l!!!!#8!$#0#0#01_(B
$B!ZL5E:2C![(B$B!ZL}@-![(B

$B!Z $BHi;i@.J,!&?"J*@-%;%i%_%I!&%7%j%+%^%$%/%m%+%W%;%k(B

$B#3#0#g!!!!#6!$#8#0#01_(B
$BHiIfI=LL$K%"%/%"$N%U%#%k%`$r7A@.$7!";g30@~$d(B
$B%"%l%k%2%s$J$IBN30$NM-32J* $B$7$^$9!#3Qx;6$rKI$.!"4%Ag$K$h$k(B
$B$+$f$_$rKI;_$7$^$9!#GXCf$dB-$J$IA4?H$K;HMQ(B
$B$G$-$^$9!#(B
$B?M$NHi;i$HF1 $BG[9g$7!"F}2=:^$r;H$o$J$$FC5v@=K!$K$h$kL5E:2C(B
$BHi;i%/%j!<%`$G$9!#BN29$G=y!9$K$H$1D9;~4V8z2L(B
$B$rJ];}$7$^$9!#?eJ,$N>x;6$rKI$.$+$f$_$N860x(B
$B$rM^$($F$7$C$H$jH)$r0];}$7$^$9!#(B
$B@0!!H)(B
$B4%Ag2CNpH)J]<>(B $B4%Ag2CNpH)J]<>(B
$B!Z(B13$B![ $B"#%S!<%P%s%8%g%"#3#1#5"#(B $B!Z#1#4![4T85%*%$%k(B
$B"#%S!<%P%s%8%g%"#6#0#1"#(B
$B!Z$B!ZL}@-!??e@-![(B

$B!Z $B%*%&%4%s!&%7%3%s!&%=%&%O%/%R!&%9%/%o%i%s!&%[%[%PL}!&%m!<%:%^%j!

$B#4#0#g!!!!#6!$#0#0#01_(B
$B!ZL5E:2C![(B$B!ZL}@-![(B

$B!Z $B%9%/%o%i%s!&L}@-4EAp!&%*%&%4%s(B

$B#3#0#m#l!!!!#6!$#0#0#01_(B
$B%9%/%o%i%sEy$NE7A3L}@-@.J,$HOB4A$N?"J*@.J,!"(B
$B%O!<%V@.J,$,$*H)$r$7$C$H$j=a$7!"HiIfI=LL$K(B
$B
$B?<3$;-M3Mh$N%9%/%o%i%s%*%$%k$r%Y!<%9$KL}@-(B
$B4EAp!"%*%&%4%s$J$I?"J*@-J]<>@.J,$rG[9g$7(B
$B$^$7$?!#H~Gr$O$b$A$m$s>.$8$o$dH)9S$l$K$b(B
$B8z2L$rH/4x$7$^$9!#%^%C%5!<%8%*%$%k$H$7$F$b(B
$B$4;HMQ2<$5$$!#(B

UV$B!&%U%!%s%G!<%7%g%s(B
UV$B%Y!<%9(B $BH~!!H)(B
$B!Z#1#5![(BUV$B%(%C%;%s%7%c%k%Y!<%9(B
$B"#%S!<%P%s%8%g%"#4#8#0"#(B		 $B!Z#1#6![%j%s%/%k%j%U%F%#%s%0%U%!%s%G!<%7%g%s(B
$B"#%S!<%P%s%8%g%"#4#6#0"#(B
$B!Z$B!ZL}@-!??e@-![(B

$B!Z $BHyN3;R(BY$B%A%?%s!&%*%&%4%s!&%9%/%o%i%s(B

$B#5#m#l'7#5K\!!!!#8!$#8#0#01_(B
$B!Z$B!ZL}@-!??e@-![(B
$B!Z?'!'%J%A%e%i%k%T%s%/![(B

$B!Z $B%^%$%/%m%;%i%_%C%/%Q%&%@!

$B#2#5#m#l!J%9%]%s%8IU!K!!#8!$#0#0#01_(B
$B;g30@~(BA$BGH!"(BB$BGH$r#9#9!s0J>e5[<}%+%C%H$7!"%7%_$N860x(B
$B$K$J$k%a%i%K%s$rH/@8$5$;$^$;$s!#GvEI$jAGH)463P$G(B
$BD9;~4V8z2L$,;}B3$7!"$*H)$O2P>H$i$:H);I7c$b$"$j$^$;$s!#(B
$B!Z(BY$B%A%?%s![$OFC5v@=K!$K$h$k%S!<%P%s%8%g%"$@$1$N(BUV$B5[<}@.J,$G$9!#(B
$B5$$K$J$k%7%o$N1"1F$r%+%P!<$7$J$,$i!"LS7j$r0z$-Dy$a(B
$B$*4iA4BN$r%j%U%F%#%s%0$7$^$9!#HiIfI=LL$KJ]<>J]8nKl(B
$B$r7A@.$7!"4%Ag$d;g30@~$+$iHiIf$r%,!<%I$7$^$9!#(B
$B$5$i$KFbLL$+$i$bF/$-$+$1$F!"H) $B$r2~A1$7$^$9!#(B
UV$B!&%U%!%s%G!<%7%g%s(B
$BH~!!Gr(B $B;E>e$2(B
$B!Z#1#7![%7%_@lMQ%+%P!<%U%!%s%G!<%7%g%s(B
$B"#%S!<%P%s%8%g%"#7#1#1(BK$B"#(B		 $B!Z#1#8![(BUV$B%+%C%H%W%l%9%H%Q%&%@!<(B
$B"#%S!<%P%s%8%g%"#4#1#1(BK$B"#(B
$B!Z?'!'%i%$%H%*!<%/%k![(B$B!ZL}@-![(B

$B!Z $BL}@-4EAp!&E7A3%S%?%_%s(BE$B!&%+%m%C%H(B

$B!J%1!<%9IU!K!!#8!$#0#0#01_(B
$B!J%l%U%#!]%k!K!!#7!$#5#0#01_(B
$B!Z?'!'%J%A%e%i%k![!Z%Q%&%@!
$B!Z $BHyN3;R(BY$B%A%?%s!&%^%$%/%m%Q%&%@!<(B

$B!J%1!<%9IU!K!!#6!$#0#0#01_(B
$B!J%l%U%#!]%k!K!!#5!$#5#0#01_(B
$B5$$K$J$k%7%_!"$/$9$_$r%+%P!<$7$F!"%J%A%e%i%k$K;E>e$2(B
$B$^$9!#L}@-;@2=KI;_:^$dH~Gr@.J,G[9g$G!";g30@~$d(B
$B3h@-;@AG$J$ICk4V$NM-32J*$+$iD9;~4V$*H)$rJ]8n$7$^$9!#(B
$BD+$N%9%-%s%1%"$N;E>e$2!"30=P;~$*2=>QD>$7$N(BUV$B%1%"(B
$B$K;H$$$^$9!#<+A3$JGr$5$NAGH)463P$K;E>e$,$k%k!<%;%s%H(B
$B%?%$%W$G$9!#$3$^$a$K2=>QD>$7$9$k$3$H$GF|>o;g30@~$O(B
$B$[$\#1#0#0!s%+%C%H=PMh$^$9!#(B
$B%j%C%W(B
$B%j%C%W%Y!<%9(B $BHy%"%k%+%j@-(B
$B!Z#1#9![%j%C%W%Y!<%k%(%C%;%s%9(B
$B"#%S!<%P%s%8%g%"#7#8#0"#(B		 $B!Z#2![9ZAG@v4i(BC$B%Q%&%@!<(B
$B"#%S!<%P%s%8%g%"#2#0#1(BC$B"#(B$B!ZJ,Jq![(B
$B!Z$B!Z?e@-![(B
$B!Z%^%$%/%m%+%W%;%kF~$j![(B

$B!Z $B%-%H%5%s!&%*%&%4%s!&%0%j%;%j%s(B

$B#1#2#g!!#5!$#8#0#01_(B
$B!Z
$B#5#5JqF~!J%U%)!<%_%s%0%7%'%$%+!$B!!(B$B#3!$#8#0#01_(B
$B#8#0JqF~!J%U%)!<%_%s%0%7%'%$%+!$B!!(B$B#5!$#3#0#01_(B
$B$D$1$k$H?0I=LL$KJ]<>J]8nKl$,7A@.$5$l4%Ag$rKI$.$^$9!#(B
$B$8$o!<$H$"$?$?$+$/$J$j%^%C%5!<%88z2L$G?0$,%T%s%/?'$K(B
$B51$-!";g30@~$r%+%C%H$7$F!"?0$N=D$8$o!"$/$9$_$r2~A1$7$^$9!#(B
$BD+!"Lk$4;HMQ2<$5$$!#(B
$BJ,Jq#1Jq$,@v4i#12sJ,$G$9!##5#5JqF~$j$K$O%U%)!<%_%s%0(B
$B%7%'%$%+! $B

$B>\:Y>pJs!<%S!<%P%s%8%g%"2=>QIJ!J%a!<%+!<(BHP$B!K(B

$B$49XF~$O!"<+A3?)IJ@lLgE9$/$k$_$d!V3ZE7E9!W$r$4MxMQ$/$@$5$$"v"v"v(B

$B!!(B$B!!(B